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Pancreatic diseases: pancreatitis, cysts and tumours

The pancreas makes digestive enzymes and insulin. Its diseases range from pancreatitis to cysts and cancer, and many can be treated without open surgery.

Medically reviewed by Dr Vishal Kumar Chorasiya, MBBS, MS, FACS · Last updated 30 Sep 2026
Liver, pancreas and bile duct surgery

Key facts

  • Acute pancreatitis: Usually caused by gallstones or alcohol.
  • Chronic pancreatitis: Causes long-term pain, diabetes and poor digestion.
  • Cysts and tumours: Many cysts are harmless and only need monitoring; some need removal.
  • Surgery for pancreatitis: Most acute pancreatitis is treated without an operation.
  • Pancreatic cysts: Cysts are often found by chance on scans.
On this page

Acute pancreatitis

Usually caused by gallstones or alcohol. Most cases settle with hospital care; infected fluid collections may need endoscopic or keyhole drainage.

Chronic pancreatitis

Causes long-term pain, diabetes and poor digestion. Surgery (such as Frey or Whipple) helps when medicines and endoscopy fail.

Cysts and tumours

Many cysts are harmless and only need monitoring; some need removal. Tumours are assessed with CT, MRI and endoscopic ultrasound.

Acute vs chronic pancreatitis

Acute pancreatitis Chronic pancreatitis
Onset Sudden severe upper abdominal pain, often going to the back Long-term or recurring pain
Common causes Gallstones, alcohol, high triglycerides Alcohol, tropical (idiopathic) pancreatitis, genetics
Course Most recover fully Permanent damage over time
Complications Fluid collections, infected necrosis Diabetes, poor digestion, stones in the duct
Treatment Hospital care; drainage if infected; gallbladder removal Pain control, enzymes, endoscopy, surgery

Surgery for pancreatitis

Most acute pancreatitis is treated without an operation. Infected dead tissue (necrosis) is drained by endoscopy or keyhole surgery in a stepwise approach. After gallstone pancreatitis, the gallbladder is removed to prevent another attack. In chronic pancreatitis with a dilated duct or stones, a Frey or similar operation drains the duct and relieves pain when endoscopy has failed.

Pancreatic cysts

Cysts are often found by chance on scans. Most are harmless, but some types (mucinous cysts and IPMN) can turn into cancer. MRI and endoscopic ultrasound help decide which cysts only need watching and which should be removed.

Pancreatic cancer

Warning signs include painless jaundice, unexplained weight loss, new diabetes after the age of 50, and back pain. Surgery, such as a Whipple operation or distal pancreatectomy, combined with chemotherapy gives the best chance of cure when the cancer has not spread.

Frequently asked questions

What is the difference between acute and chronic pancreatitis?

Acute pancreatitis is a sudden inflammation that usually settles completely. Chronic pancreatitis is long-term damage that causes recurring pain, diabetes and poor digestion.

Can pancreatitis be cured?

Acute pancreatitis usually heals fully, especially when the cause, such as gallstones, is treated. Chronic pancreatitis cannot be reversed, but pain and digestion can be well controlled.

When does pancreatitis need surgery?

When infected fluid or dead tissue needs draining, to remove the gallbladder after gallstone pancreatitis, or for chronic pancreatitis pain that does not respond to other treatment.

Are all pancreatic cysts cancerous?

No. Most are benign. Some types carry a risk of cancer and are watched closely or removed.

What are the early signs of pancreatic cancer?

Painless jaundice, weight loss, loss of appetite, new-onset diabetes and upper abdominal or back pain.

Dr Vishal Kumar Chorasiya
Reviewed byDr Vishal Kumar Chorasiya

Group Director – Liver Transplant, HPB, GI & Robotic Surgery, Yatharth Group of Hospitals. 18+ years in liver transplantation.

This page is for general information and is not a substitute for medical advice. Speak to the transplant team for a personal assessment.

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